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    Fuse Box Diagram & Amperage

    2021 GMC Sierra 2500HD Fuse Box Diagram & Amperage

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    Quick answer

    The 2021 GMC Sierra 2500HD has three main fuse box locations: under the hood (engine compartment), inside the cabin (driver's side dash kick panel), and in the rear (under the rear seat on the driver's side).

    Having issues with your 2021 GMC Sierra 2500HD's electrical system? A blown fuse could be the culprit! This guide provides a comprehensive overview of the fuse box locations, diagrams, amperage ratings, and the circuits they protect. Remember to always consult your vehicle's owner's manual and the fuse box lid for the most accurate and up-to-date information, as fuse configurations can vary slightly due to trim levels and options.

    Under-Hood Fuse Box

    The under-hood fuse box is located in the engine compartment, typically on the driver's side near the battery. It contains fuses and relays for critical engine functions, powertrain control, major electrical systems, and trailer connections.

    Fuse #AmpColorCircuit / Component Protected
    F160AYellowMain Power (Ignition 1)
    F260AYellowMain Power (Ignition 2)
    F350ARedABS Pump Motor
    F440AGreenTrailer Brake Control
    F530AGreenBlower Motor
    F630AGreenECM/PCM (Powertrain Control Module)
    F725ANaturalFuel Pump
    F820AYellowHeadlights (Low Beam - Left)
    F920AYellowHeadlights (Low Beam - Right)
    F1015ABlueIgnition Coils
    F1115ABlueStarter Relay
    F1210ARedA/C Compressor Clutch
    F1310A RedTail Lights (Left)
    F1410A RedTail Lights (Right)
    F1520A YellowBCM (Body Control Module) Supply
    F1625A NaturalTrailer Power (Constant)
    F1730A GreenPower Mirror / Power Window

    Relay Locations (Under-Hood):

    • RL1 (Starter Relay): Controls power to the starter motor.
    • RL2 (Fuel Pump Relay): Powers the fuel pump.
    • RL3 (Ignition Relay): Supplies power to the ignition system.
    • RL4 (Headlight Relay): Controls headlight operation.
    • RL5 (Blower Motor Relay): Powers the blower motor for HVAC.
    • RL6 (A/C Clutch Relay): Engages and disengages the A/C compressor clutch.
    • RL7 (Trailer Brake Relay): Provides power for the trailer brake controller.

    Cabin Fuse Box (Instrument Panel Fuse Block)

    The cabin fuse box is located inside the vehicle on the driver's side, typically behind a removable panel on the side of the dashboard (the kick panel). This fuse box primarily handles interior electrical components, accessories, and convenience features.

    Fuse #AmpColorCircuit / Component Protected
    F125ANaturalBlower Motor (HVAC System)
    F220AYellowRadio / Infotainment System
    F315ABlueAccessory Power Outlet (Cigar Lighter)
    F415ABlueUSB Ports / Auxiliary Power
    F510ARedInstrument Cluster
    F610ARedABS Module (Control)
    F710ARedAirbag (SRS) System
    F810ARedBrake Lights
    F95ATanECM/PCM (Keep Alive Memory)
    F105ATanIgnition Switch
    F1115ABluePower Windows
    F1215ABluePower Door Locks
    F1310ARedInterior Lights / Dome Light
    F145ATanHVAC Control Head
    F1520AYellowTrailer Brake Controller (Cabin)

    Rear Fuse Box

    The rear fuse box in the 2021 GMC Sierra 2500HD is typically located under the rear seat on the driver's side. This fuse box often contains fuses for electrical components found in the rear of the vehicle, such as trailer connections, power outlets, and certain body control functions.

    Fuse #AmpColorCircuit / Component Protected
    F140AGreenTrailer Auxiliary Power
    F230AGreenPower Inverter (If Equipped)
    F320AYellowRear Accessory Power Outlet
    F420AYellowRear Window Defogger
    F515ABlueTrailer Stop/Turn Lights (Left)
    F615ABlueTrailer Stop/Turn Lights (Right)
    F710ARedTrailer Park/Tail Lights

    How to Test a Fuse

    If you suspect a blown fuse, here's how to safely test it:

    1. Locate the Fuse Box: Refer to your owner's manual or the quick answer section above to find the correct fuse box.
    2. Identify the Suspect Fuse: Open the fuse box lid and consult the diagram on the lid or in your owner's manual to find the fuse for the problematic component.
    3. Carefully Remove the Fuse: Use a fuse puller (usually found within the fuse box or tool kit) to gently remove the suspect fuse. Never use metal tools that could short circuits.
    4. Inspect the Fuse: Hold the fuse up to a light and look for a broken wire inside the fuse. If the wire is broken or charred, the fuse is blown. For blade-type fuses, you can also look for discoloration.
    5. Use a Multimeter (Optional but Recommended): For a more definitive test, set your multimeter to the continuity setting. Touch one probe to each metal terminal of the fuse. A good fuse will show continuity (the multimeter will beep or display a reading close to zero ohms). A blown fuse will show no continuity.
    6. Replace with a New Fuse: If the fuse is blown, replace it with a new fuse of the exact same amperage rating and type. Never use a fuse with a higher amperage, as this can lead to serious electrical damage or fire.

    Common Blown Fuses on This Vehicle

    While any overcurrent situation can blow a fuse, some fuses are more commonly affected due to their circuits or components. Here are a few to check first if you're experiencing related issues:

    • Cigar Lighter / 12V Outlets: These fuses (often F3 in the cabin fuse box) are frequently blown due to short circuits from chargers, air fresheners, or other accessories. If your phone isn't charging, this is a good place to start.
    • Blower Motor: If your HVAC fan isn't working on any speed, check the blower motor fuse (F5 in the under-hood fuse box or F1 in the cabin fuse box, depending on the fault). A failing blower motor or a blockage can draw excessive current.
    • Headlights: If one or both of your headlights are out, check their respective fuses (F8 and F9 in the under-hood fuse box). While bulbs are a more common failure, a short in the wiring can blow the fuse.
    • Trailer Brake Control: For those who frequently tow, the trailer brake control fuse (F4 in the under-hood or F15 in the cabin) can blow if there's a short in the trailer's wiring or the brake controller itself. Always inspect your trailer's wiring before troubleshooting the truck.

    Always verify the printed legend in the fuse box lid against your owner's manual, as certain trim levels or optional equipment may have slight variations in fuse assignments.

    Find a trusted shop on Repairius.

    Before you pull a fuse on the 2021 GMC Sierra 2500HD

    • Use the label printed on the panel cover or the owner's manual for your exact build. Layouts change with options, model year and build date, so a chart for another truck can be wrong.
    • Replace a blown fuse only with the same amp rating. A larger fuse can let wiring overheat.
    • A fuse that blows again right away means a short or failing component downstream. Find the cause before replacing it again.
    • A good fuse doesn't prove the circuit works — relays, grounds and connectors fail too.
    • Disconnect the battery before working near high-current fuses or cables.

    Learn more: How fuses, relays and truck electrical systems work

    Need service on your GMC Sierra 2500HD?

    Request service from shops in your area.

    More specs for the 2021 GMC Sierra 2500HD

    Oil Capacity & Filter

    Capacity, weight, filter PN, drain plug torque, change interval.

    Fluid Type Specs

    Engine oil, coolant, ATF, diff, brake, PS, DEF — with OEM spec numbers.

    Coolant Capacity & Type

    Total system capacity, OEM coolant spec, flush interval, bleed tips.

    Transmission Fluid & Service

    Trans model, fluid spec, capacity, filter PN, service interval.

    Torque Specifications

    Lug nuts, drain plug, caliper, axle nut, plug, key fasteners.

    Brake Pad & Rotor Specs

    Pad PNs, rotor size, min thickness, caliper torque.

    Tire Size & Pressure

    OEM size, cold psi, bolt pattern, wheel size, TPMS.

    Battery Size & Group

    Group size, CCA, AGM/flooded, dimensions, reset note.

    A/C Refrigerant & Oil

    R-134a or R-1234yf, charge oz, PAG oil spec.

    Bulb Sizes (Headlight, Tail, Fog)

    Headlight, fog, tail, turn, reverse, interior.

    Factory Maintenance Schedule

    Service intervals by mileage, severe-duty notes, known issues.

    Towing Capacity & Payload

    Max tow, payload, GVWR/GCWR, hitch class by trim.

    Serpentine Belt Routing & Length

    Belt routing, length, rib count, OEM + aftermarket PNs.

    Wheel Alignment Specifications

    Camber, caster, toe ranges (front & rear), adjustability notes.

    Paint Color Codes

    All factory colors with paint codes, sticker location, touch-up tips.

    Wiper Blade Sizes

    Driver/passenger/rear blade size, attachment, OEM + cross-refs.

    Spark Plug Type & Gap

    Plug PN, gap, torque, interval by engine.

    Transmission & Axle Gear Ratios

    Trans gear ratios, axle ratios, RPO codes, tow vs MPG impact.

    Key Fob Programming

    DIY programming steps, FCC ID, fob PN, battery, transponder.

    Same spec — other model years

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    Values can vary by engine, trim and build date; check your VIN-specific service information. Updated 2026-06-26.

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